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Browsing by Author "Kuş, Melih"
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Iron-promoted 1,5-substitution (SN2′′) reactions of enyne acetates and oxiranes with Grignard reagents
Taç, Doğan; Aytaç, İsmet Arınç; Karatavuk, Ali Osman; Kuş, Melih; Ziyanak, Fırat; Artok, Levent (Wiley, 2017-10)Acetate derivatives of 2-en-4-yne alcohols 1 and enyne oxiranes 4 regioselectively underwent 1,5-substitution (SN2′′) reactions with Grignard reagents in the presence of an iron compound to provide vinylallenes exclusively ... -
Palladium-catalyzed alkoxycarbonylation of (Z)-2-En-4-yn carbonates leading to 2,3,5-trienoates
Akpınar, G. Eray; Kuş, Melih; Üçüncü, Muhammed; Karakuş, Erman; Artok, Levent (American Chemical Society, 2011-02-18)Pd(0)-catalyzed carbonylation of (Z)-2-en-4-yn carbonates in the presence of a balloon pressure of CO in an alcohol donates vinylallenyl esters with an exclusively E-configuration and in high yields. The fact that no such ... -
Palladium-catalyzed alkoxycarbonylation of conjugated enyne oxiranes: A diastereoselective method for the synthesis of 7-hydroxy-2,3,5-trienoates
Kuş, Melih; Artok, Levent; Aygün, Muhittin (American Chemical Society, 2015-06-05)Palladium-catalyzed alkoxycarbonylative 1,5-substitution of conjugated enyne oxiranes provides a diastereoselective route to (E)-configured 7-hydroxy-2,3,5-trienoates. The reactions proceeded in a highly stereoselective ... -
Regio- and stereoselective synthesis of 2,3,5-trienoates by palladium-catalyzed alkoxycarbonylation of conjugated enyne carbonates
Karagöz, Ezgi Şule; Kuş, Melih; Akpınar, Gürkan Eray; Artok, Levent (American Chemical Society, 2014-10)Palladium-catalyzed carbonylation of 2,4-enyne carbonates in an alcohol and under balloon pressure of CO proceeds through 1,5-substitution to yield (E)-2,3,5-trienoates. The olefin geometry of the substrate is important ... -
Rhodium catalysed chemo- and stereoselective arylative and alkenylative cyclisation reactions of unsymmetric diynes containing a terminal alkyne moiety with organoboronic acids
Artok, Levent; Kuş, Melih; Ürer, Bağdagül N.; Türkmen, Gülşah; Aksın Artok, Özge (Royal Society of Chemistry, 2010)Unsymmetric diynes possessing a terminal alkyne moiety reacted with organoboronic acids both chemo- and stereoselectively to afford arylated or alkenylated exocyclic dienes by catalysis from the [Rh(cod)OCH 3] 2 complex. ... -
Rhodium catalyzed reaction of internal alkynes with organoborons under CO atmosphere: a product tunable reaction
Artok, Levent; Kuş, Melih; Aksın, Özge; Dege, Fatma Nurcan; Özkılınç, Fatma Yelda (Elsevier, 2009-11)Alkynes react with organoborons under a CO atmosphere in the presence of a rhodium(I) catalyst to afford mainly 5-aryl-2(5H)-furanones, α,β-unsaturated ketones, and indanones. The product selectivity can be tuned by modifying ... -
Rhodium- and palladium-catalyzed 1,5-substitution reactions of 2-En-4-yne acetates and carbonates with organoboronic acids
Üçüncü, Muhammed; Karakuş, Erman; Kuş, Melih; Akpınar, Gürkan Eray; Aksın Artok, Özge; Krause, Norbert; Karaca, Sıla; Nuran, Elmacı; Artok, Levent (American Chemical Society, 2011-08)Two methods involving the rhodium-catalyzed reaction of 2-en-4-yne acetates and the palladium-catalyzed reaction of 2-en-4-yne carbonates with organoboronic acids were investigated; both afforded exclusively the (E)-configured ... -
Rhodium-catalysed alkoxycarbonylative cyclisation reactions of 1,6-enynes
Ziyanak, Fırat; Kuş, Melih; Artok, Levent (Wiley-VCH Verlag, 2011-04)The rhodium-catalysed carbonylation of 1,6-enynes possessing an electron-deficient alkenyl moiety in an alcohol reagent in the presence of a rhodium complex proceeded stereo- and chemoselectively to afford exocyclic α,β-enoates. -
Synthesis of α,β-unsaturated ketones by rhodium-catalyzed carbonylative arylation of internal alkynes with arylboronic acids
Kuş, Melih (İzmir Institute of Technology, 2009)α,β-Unsaturated ketones are important key reagents in organic synthesis. They are commonly synthesised through an aldol condensation reaction.Since Hayashi et al. reported the first Rh-catalyzed addition of aryl- and ... -
Synthesis of α,β-unsaturated ketones by rhodium-catalyzed carbonylative arylation of internal alkynes with arylboronic acids
Kuş, Melih; Aksın Artok, Özge; Ziyanak, Fırat; Artok, Levent (Georg Thieme Verlag, 2008-10)The Rh-catalyzed reaction of arylboronic acids with internal alkynes under a CO atmosphere in the presence of an acid additive afforded α,β-unsaturated ketones as the major products. Hydroacylation of internal alkynes, ... -
Transition metal catalyzed 1,5-substitutionreactions of conjugated enyne oxiranes leading to allylic hydroxy substituted vinylallenes
Kuş, Melih (İzmir Institute of Technology, 2015-08)Transition metal-catalyzed reactions are atom economical and environmentally benign processes, which make them superior to traditional stoichiometric reactions. Transition metal-catalyzed carbonylation reactions of unsaturated ...
