Browsing by Author "Aypek, Hande"

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Alteration of protein localization and intracellular calcium content due to connexin26 D50A and A88V mutations

Aypek, Hande; Meşe, Gülistan (Türk Biyokimya Derneği, 2017-04)

Introduction: Connexins (Cx) play essential roles in cellular homeostasis by forming gap junctions and non-junctional hemichannels. In vitro characterization of Cx26 mutations causing keratitis-ichthyosis-deafness (KID) ...
Altered cellular localization and hemichannel activities of KID syndrome associated connexin26 I30N and D50Y mutations

Aypek, Hande; Bay, Veysel; Meşe, Gülistan (BioMed Central, 2016-02)

Background: Gap junctions facilitate exchange of small molecules between adjacent cells, serving a crucial function for the maintenance of cellular homeostasis. Mutations in connexins, the basic unit of gap junctions, are ...
Deciphering functions of aberrant hemichannels formed by connexin 26- I30N and D50Y mutations

Aypek, Hande (Izmir Institute of Technology, 2015-07)

Cells need to communicate with each other for maintenance cellular and tissue homeostasis. Gap junctions are channel-forming structures that are formed by docking of two hemichannels on the plasma membrane of adjacent ...