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dc.contributor.authorGüneş, Seda
dc.contributor.authorTıhmınlıoğlu, Funda
dc.date.accessioned2018-01-03T10:23:38Z
dc.date.available2018-01-03T10:23:38Z
dc.date.issued2017-09
dc.identifier.citationGüneş, S., and Tıhmınlıoğlu, F. (2017). Hypericum perforatum incorporated chitosan films as potential bioactive wound dressing material. International Journal of Biological Macromolecules, 102, 933-943. doi:10.1016/j.ijbiomac.2017.04.080en_US
dc.identifier.issn0141-8130
dc.identifier.urihttp://doi.org/10.1016/j.ijbiomac.2017.04.080
dc.identifier.urihttp://hdl.handle.net/11147/6636
dc.description.abstractRecent studies in wound dressing applications offer new therapies and promote wound healing process. The aim of this study was to develop Hypericum perforatum (St John's Wort) oil incorporated chitosan films for wound dressing applications. H. perforatum oil as a potential therapeutic agent was encapsulated in chitosan film to achieve a better wound dressing material. Oil incorporated chitosan films were successfully prepared by solvent casting method in different oil concentrations (0.25–1.5%v/v). Water vapor permeability (WVP), mechanical test, swelling behavior and surface hydrophobicity were performed in order to characterize the prepared films. Antimicrobial test was performed by disc diffusion method and the growth inhibition effects of the films including different amount of H. perforatum oil were investigated on Escherichia coli and Staphylococcus aureus. WVP increased with oil incorporation and the highest value was obtained for 0.25% oil concentration.The highest strain value was obtained in 0.25% oil content films although tensile stress decreased with increasing oil content. H. perforatum oil incorporated films had antimicrobial effect on both microorganisms. Chitosan based films had no cytotoxic effects on NIH3T3fibroblast cells and provided a good surface for cell attachment and proliferation. The results showed that the H. perforatum incorporated chitosan films seems to be a potential and novel biomaterial for wound healing applications.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.ijbiomac.2017.04.080en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntimicrobial activityen_US
dc.subjectCell attachmenten_US
dc.subjectChitosanen_US
dc.subjectWound dressingsen_US
dc.subjectHypericum perforatum oilen_US
dc.titleHypericum perforatum incorporated chitosan films as potential bioactive wound dressing materialen_US
dc.typearticleen_US
dc.contributor.authorIDTR1143en_US
dc.contributor.iztechauthorGüneş, Seda
dc.contributor.iztechauthorTıhmınlıoğlu, Funda
dc.relation.journalInternational Journal of Biological Macromoleculesen_US
dc.contributor.departmentİYTE, Mühendislik Fakültesi, Kimya Mühendisliği Bölümüen_US
dc.identifier.volume102en_US
dc.identifier.startpage933en_US
dc.identifier.endpage943en_US
dc.identifier.wosWOS:000406984300102
dc.identifier.scopusSCOPUS:2-s2.0-85018306007
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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