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Browsing by Author "Baran, Yusuf"
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5-Fluorouracil signaling through a calcium-calmodulin-dependent pathway is required for p53 activation and apoptosis in colon carcinoma cells
Can, G.; Akpınar, B.; Baran, Yusuf; Zhivotovsky, B.; Olsson, M. (Nature Publishing Group, 2013-09)5-Fluorouracil (5-FU) is an anti-metabolite that is in clinical use for treatment of several cancers. In cells, it is converted into three distinct fluoro-based nucleotide analogs, which interfere with DNA synthesis and ... -
Activated signaling pathways and apoptotic mechanisms in resveratrol applied chronic myeloid leukemia cells and the involvement of ceramide metabolizing genes on these mechanisms
Kartal, Melis (Izmir Institute of Technology, 2010)Resveratrol, an important phytoalexin in many plants, has cytotoxic effects on several cancer cells. Ceramide is a significant sphingolipid which affects many signaling pathways regulating cell senescence, migration, and ... -
Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells
Çinçin, Zeynep Birsu; Ünlü, Miray; Kıran, Bayram; Bireller, Elif Sinem; Baran, Yusuf; Çakmakoğlu, Bedia (Springer, 2015-06-29)Purpose: Hesperidin, a glycoside flavonoid, is thought to act as an anti-cancer agent, since it has been found to exhibit both pro-apoptotic and anti-proliferative effects in several cancer cell types. The mechanisms ... -
Apoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cells
Kiraz, Yağmur; Neergheen-Bhujun, Vidushi S.; Rummun, Nawraj; Baran, Yusuf (Springer, 2016-02)Multiple myeloma is of great concern since existing therapies are unable to cure this clinical condition. Alternative therapeutic approaches are mandatory, and the use of plant extracts is considered interesting. Punica ... -
Apoptotic effects of quercitrin on DLD-1 colon cancer cell line
Çinçin, Zeynep Birsu; Ünlü, Miray; Kıran, Bayram; Bireller, Elif Sinem; Baran, Yusuf; Çakmakoğlu, Bedia (Springer, 2014-08)Quercetin, which is the most abundant bioflavonoid compound, is mainly present in the glycoside form of quercitrin. Although different studies indicated that quercitrin is a potent antioxidant, the action of this compound ... -
Apoptotic effects of resveratrol, a grape polyphenol, on imatinib-sensitive and resistant K562 chronic myeloid leukemia cells
Can, Geylani; Çakır, Zeynep; Kartal, Melis; Gündüz, Ufuk; Baran, Yusuf (International Institute of Anticancer Research, 2012-07)To examine the antiproliferative and apoptotic effects of resveratrol on imatinib-sensitive and imatinib-resistant K562 chronic myeloid leukemia cells. Antiproliferative effects of resveratrol were determined by the ... -
Autologous rabbit adipose tissue-derived mesenchymal stromal cells for the treatment of bone injuries with distraction osteogenesis
Sunay, Özgür; Can, Geylani; Çakır, Zeynep; Denek, Ziya; Kozanoǧlu, İlknur; Erbil, Güven; Yılmaz, Mustafa; Baran, Yusuf (Elsevier, 2013-06)Background aims: Adipose tissue-derived mesenchymal stromal cells (MSCs) have a higher capacity for proliferation and differentiation compared with other cell lineages. Although distraction osteogenesis is the most important ... -
Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells
Başsoy, Esen Yonca; Baran, Yusuf (Elsevier, 2012-03)In this study, we examined the possible roles of ceramide/sphingosine-1-phosphate and ceramide/glucosyleceramide signaling in docetaxel-induced apoptosis by examining expression levels of the glucosyleceramide synthase and ... -
Bioactive Sphingolipids in response to chemotherapy: A scope on Leukemias
Ekiz, Hüseyin Atakan; Baran, Yusuf (Bentham Science Publishers, 2011-05)Sphingolipids are major constituents of the cells with emerging roles in the regulation of cellular processes. Deregulation of sphingolipid metabolism is reflected as various pathophysiological conditions including metabolic ... -
Bioactive, functional and edible film-forming properties of isolated hazelnut (Corylus avellana L.) meal proteins
Aydemir, Levent Yurdaer; Adan Gökbulut, Aysun; Baran, Yusuf; Yemenicioğlu, Ahmet (Elsevier, 2014-05)This study aimed characterization of bioactive, functional and edible film making properties of isolated proteins from untreated (HPI), hot extracted (HPI-H), acetone washed (HPI-AW), and acetone washed and hot extracted ... -
Biodiversity, drug discovery, and the future of global health: Introducing the biodiversity to biomedicine consortium, a call to action
Neergheen-Bhujun, Vidushi; Awan, Almas Taj; Baran, Yusuf; Bunnefeld, Nils; Chan, Kit; Dela Cruz, Thomas Edison; Egamberdieva, Dilfuza; Elsasser, Simon; Johnson, Mari-Vaughn V.; Komai, Shoji; Konevega, Andrey L.; Malone, John H.; Mason, Paul; Nguon, Rothsophal; Piper, Ross; Shrestha, Uttam Babu; Pesic, Milica; Kagansky, Alexander (University of Edinburgh, 2017-11)Looking to nature for medicine is nothing new – we have been doing it for tens of thousands of years and although modern pharmaceutical science has come a long way from those ancient roots, nature is and will always be ... -
Bisphosphonate treatment and radiotherapy in metastatic breast cancer
Ural, Ali Uğur; Avcu, Ferit; Baran, Yusuf (Humana Press, 2008-09)Patients with advanced breast cancer frequently develop metastasis to bone. Bone metastasis results in intractable pain and high risk of pathologic fractures due to osteolysis. The treatment of breast cancer patients with ... -
Caffeic acid phenethyl ester triggers apoptosis through induction of loss of mitochondrial membrane potential in CCRF-CEM cells
Avcı, Çığır Biray; Gündüz, Cumhur; Baran, Yusuf; Şahin, Fahri; Yılmaz, Sunde; Doğan, Zeynep Özlem; Saydam, Güray (Springer, 2011)Purpose CAPE (caffeic acid phenethyl ester) is one of the most valuable and investigated component of propolis which is composed by honeybees. In the current study, we aimed at examining apoptotic effects of CAPE ... -
Cell proliferation and cytotoxicity assays
Adan, Aysun; Kiraz, Yağmur; Baran, Yusuf (Bentham Science, 2016-11)Cell viability is defined as the number of healthy cells in a sample and proliferation of cells is a vital indicator for understanding the mechanisms in action of certain genes, proteins and pathways involved cell survival ... -
Changes in protein profiles of multiple myeloma cells in response to bortezomib
Turan, Taylan; Şanlı Mohamed, Gülşah; Baran, Yusuf (Taylor & Francis, 2013-05)The objective of this study was to determine the changes in protein profiles of U-266 multiple myeloma cells in response to bortezomib. Bortezomib inhibited cell proliferation and increased the loss of mitochondrial membrane ... -
Combination of fludarabine and imatinib induces apoptosis synergistically through loss of mitochondrial membrane potential and increases in caspase-3 enzyme activity in human K562 chronic myleloid leukemia cells
Baran, Yusuf; Öztekin, Coşkun; Başsoy, Esen Yonca (Informa Healthcare, 2010-06)In this study, we aimed to show the synergistic apoptotic effects of imatinib/fludarabine combination in human K562 chronic myleloid leukemia (CML) cells. There was a significant increase in cytotoxicity of combination of ... -
Comparative development of knowledge-based bioeconomy in the European Union and Turkey
Çelikkanat Ozan, Didem; Baran, Yusuf (Informa Healthcare, 2014-09)Biotechnology, defined as the technological application that uses biological systems and living organisms, or their derivatives, to create or modify diverse products or processes, is widely used for healthcare, agricultural ... -
Deciphering 5-fluorouracil mediated molecular mechanisms required for cell death
Can, Geylani (Izmir Institute of Technology, 2011)The chemotherapy agent 5-Fluorouracil (5-FU) is an antimetabolite that has been in use to treat several cancers for decades. In cells, it is converted into three distinct fluoro-based nucleotide analogues which interfere ... -
Docetaxel enhances the cytotoxic effects of imatinib on Philadelphia positive human chronic myeloid leukemia cells
Güçlüler, Gözde; Baran, Yusuf (Taylor & Francis, 2009-06)Chronic myelogenous leukemia (CML) results from a translocation between chromosomes 9 and 22 which generates BCR/ABL fusion protein and characterized by uncontrolled proliferation of immature white blood cells. Imatinib, ... -
Docetaxel/zoledronic acid combination triggers apoptosis synergistically through downregulating antiapoptotic Bcl-2 protein level in hormone-refractory prostate cancer cells
Karabulut, B.; Erten, C.; Gül, M. K.; Cengiz, E.; Karaca, B.; Küçükzeybek, Y.; Görümlü, G.; Atmaca, H.; Uzunoğlu, S.; Şanlı, U. A.; Baran, Yusuf; Uslu, R. (Wiley, 2009-02)Docetaxel, a semi-synthetic taxane analogue, is used effectively in the treatment of metastatic prostate cancer. Zoledronic acid, the most potent member of bisphosphonates, has shown pleiotropic anti-tumoral effects on ...
