Browsing Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik by Title
Now showing items 1-20 of 290
-
1.55 Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis
(Elsevier, 2014)Background The diterpene cyclase ent-copalyl diphosphate synthase (CPS) catalyzes the first committed step in the biosynthesis of gibberellins. The previously reported 2.25 Å resolution crystal structure of CPS complexed ... -
5-Fluorouracil signaling through a calcium-calmodulin-dependent pathway is required for p53 activation and apoptosis in colon carcinoma cells
(Nature Publishing Group, 2013-09)5-Fluorouracil (5-FU) is an anti-metabolite that is in clinical use for treatment of several cancers. In cells, it is converted into three distinct fluoro-based nucleotide analogs, which interfere with DNA synthesis and ... -
Absence of superoxide dismutase activity causes nuclear DNA fragmentation during the aging process
(Elsevier, 2014-02)Superoxide dismutases (SOD) serve as an important antioxidant defense mechanism in aerobic organisms, and deletion of these genes shortens the replicative life span in the budding yeast Saccharomyces cerevisiae. Even though ... -
Advanced backcross QTL analysis of a Lycopersicon esculentum x L. pennellii cross and identification of possible orthologs in the Solanaceae
(Springer, 2004-02)In this study, the advanced backcross QTL (AB-QTL) mapping strategy was used to identify loci for yield, processing and fruit quality traits in a population derived from the interspecific cross Lycopersicon esculentum E6203 ... -
Aggregatibacter actinomycetemcomitans GroEL Protein Promotes Conversion of Human CD4+ T Cells into IFNγ IL10 Producing Tbet+ Th1 Cells
(Public Library of Science, 2012-11)One of the heat shock family protein (Hsp) expressing bacteria is the gram negative, periodontal pathogen Aggregatibacter actinomycetemcomitans (Aa). A. actinomycetemcomitans' Hsp is a 64-kDa GroEL-protein, which has been ... -
The aggregatibacter actinomycetemcomitans heat shock protein GroEL interacts directly with human peripheral blood T cells
(TÜBİTAK, 2016)Heat shock family protein GroEL of Aggregatibacter actinomycetemcomitans (Aa) has antigenic properties. We previously demonstrated that A. actinomycetemcomitans GroEL-like protein affects human CD4 T cells by converting ... -
Agrobacterium rhizogenes-mediated transformation and its biotechnological applications in crops
(Springer, 2013)The history of Agrobacterium-related plant biotechnology goes back for more than three decades with the discovery of molecular mechanisms of crown gall disease in plants. After 1980s, gene technologies began developing ... -
Algorithms for the de novo sequencing of peptides from tandem mass spectra
(Taylor & Francis, 2011-10)Proteomics is the study of proteins, their time- and location-dependent expression profiles, as well as their modifications and interactions. Mass spectrometry is useful to investigate many of the questions asked in ... -
Alteration of protein localization and intracellular calcium content due to connexin26 D50A and A88V mutations
(Türk Biyokimya Derneği, 2017-04)Introduction: Connexins (Cx) play essential roles in cellular homeostasis by forming gap junctions and non-junctional hemichannels. In vitro characterization of Cx26 mutations causing keratitis-ichthyosis-deafness (KID) ... -
Altered cellular localization and hemichannel activities of KID syndrome associated connexin26 I30N and D50Y mutations
(BioMed Central, 2016-02)Background: Gap junctions facilitate exchange of small molecules between adjacent cells, serving a crucial function for the maintenance of cellular homeostasis. Mutations in connexins, the basic unit of gap junctions, are ... -
Analysis of EST-SSRs in silver birch (Betula pendula Roth.)
(Northeast Forestry University, 2016-06)Simple sequence repeats (SSRs) defined as sequence repeat units between 1 and 6 bp occur abundantly in both coding and non-coding regions in eukaryotic genomes and these repeats can affect gene expression. In this study, ... -
Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates
(Nature Publishing Group, 2010-10)The breast epithelium has two major compartments, luminal and basal cells, that are established and maintained by poorly understood mechanisms. The p53 homolog, p63, is required for the formation of mammary buds, but its ... -
Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells
(Springer, 2015-06-29)Purpose: Hesperidin, a glycoside flavonoid, is thought to act as an anti-cancer agent, since it has been found to exhibit both pro-apoptotic and anti-proliferative effects in several cancer cell types. The mechanisms ... -
Antifungal activity of biopolymers containing natamycin and rosemary extract against Aspergillus niger and Penicillium roquefortii
(Wiley-Blackwell, 2008-11)Antimicrobial agent-releasing films have been proposed as an effective way of inhibiting chiefly surface spoilage of food products. Antifungal activities of natamycin (NA), rosemary extract (RE) and NA + RE were tested ... -
Antimicrobial activity and chemical composition screening of Anacyclus pyrethrum root
(Association of Pharmaceutical Teachers of India, 2017-07)Medical herbs have many bioactive component and they are used in microbial treatment since ancient times. The resistance of pathogens to antibiotics became a critical problem, so researches for novel antimicrobial agents ... -
Antimicrobial activity and chemical composition screening of Epilobium montanum root
(Association of Pharmaceutical Teachers of India, 2017-07)Medical herbs have many bioactive component and they are used in microbial treatment since ancient time. The resistance of pathogen to antibiotic is became a critical problem, so novel antimicrobial agent related research ... -
Antimicrobial and antioxidant activities of turkish extra virgin olive oils
(American Chemical Society, 2010-07)Turkish extra virgin olive oils (EVOO) from different varieties/ geographical origins and their phenolic compounds were investigated in terms of their antimicrobial and antioxidant properties in comparison to refined olive, ... -
Antimicrobial and antioxidant activity of edible zein films incorporated with lysozyme, albumin proteins and disodium EDTA
(Elsevier, 2007-01)In this study, partially purified lysozyme was incorporated into zein films in combination with chickpea albumin extract (CPAE), bovine serum albumin (BSA) and disodium EDTA. The zein films showed an inherent free radical ... -
Apoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cells
(Springer, 2016-02)Multiple myeloma is of great concern since existing therapies are unable to cure this clinical condition. Alternative therapeutic approaches are mandatory, and the use of plant extracts is considered interesting. Punica ... -
Apoptotic effects of quercitrin on DLD-1 colon cancer cell line
(Springer, 2014-08)Quercetin, which is the most abundant bioflavonoid compound, is mainly present in the glycoside form of quercitrin. Although different studies indicated that quercitrin is a potent antioxidant, the action of this compound ...
