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Browsing by Author "Kavallaris, Maria"
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Assessment of cholesterol-derived ionic copolymers as potential vectors for gene delivery
Sevimli, Sema; Sagnella, Sharon; Kavallaris, Maria; Bulmuş, Volga; Davis, Thomas P. (American Chemical Society, 2013-11)A library of cholesterol-derived ionic copolymers were previously synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization as 'smart' gene delivery vehicles that hold diverse surface charges. ... -
Dicer-labile PEG conjugates for siRNA delivery
Kow, Siew Ching; Mccorroll, Joshua A.; Valade, David; Boyer, Cyrille; Dwarte, Tanya; Davis, Thomas P.; Kavallaris, Maria; Bulmuş, Volga (American Chemical Society, 2011-12-12)Poly(ethylene glycol) (PEG) conjugates of Dicer-substrate small interfering RNA (DsiRNA) have been prepared to investigate a new siRNA release strategy. 3'-sense or 5'-antisense thiol-modified, blunt-ended DsiRNAs, inhibiting ... -
The endocytic pathway and therapeutic efficiency of doxorubicin conjugated cholesterol-derived polymers
Sevimli, Sema; Sagnella, Sharon; Macmillan, Alexander; Whan, Renee; Kavallaris, Maria; Bulmuş, Volga; Davis, Thomas P. (Royal Society of Chemistry, 2015-02)Previously synthesized poly(methacrylic acid-co-cholesteryl methacrylate) P(MAA-co-CMA) copolymers were examined as potential drug delivery vehicles. P(MAA-co-CMA) copolymers were fluorescently labelled and imaged in SHEP ... -
Synthesis, self-assembly and stimuli responsive properties of cholesterol conjugated polymers
Sevimli, Sema; Sagnella, Sharon; Kavallaris, Maria; Bulmuş, Volga; Davis, Thomas P. (Royal Society of Chemistry, 2012-08)Reversible addition-fragmentation chain transfer (RAFT) polymerization was used to generate well-defined pH-responsive biofunctional polymers as potential 'smart' gene delivery systems. A series of five poly(dimethylamino ...
