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dc.contributor.authorKasaplar, Pınar
dc.contributor.authorYılmazer, Özgür
dc.contributor.authorÇağır, Ali
dc.date.accessioned2017-04-03T11:55:04Z
dc.date.available2017-04-03T11:55:04Z
dc.date.issued2009-01
dc.identifier.citationKasaplar, P., Yılmazer, Ö. and Çağır, A.(2009). 6-Bicycloaryl substituted (S)- and (R)-5,6-dihydro-2H-pyran-2-ones: Asymmetric synthesis, and anti-proliferative properties. Bioorganic and Medicinal Chemistry, 17(1), 311-318. doi:10.1016/j.bmc.2008.10.069en_US
dc.identifier.issn0968-0896
dc.identifier.urihttp://dx.doi.org/10.1016/j.bmc.2008.10.069
dc.identifier.urihttp://hdl.handle.net/11147/5204
dc.description.abstract(R)-Goniothalamin, is a member of styryl lactones, possesses selective cytotoxicity against cancer cell lines. In this work, replacement of styryl substituent with 2-naphthyl and 3-quinoyl gave new analogues which may have less conformational changes compared to the lead compound. Anti-proliferative tests indicated that 2-naphthyl substituted (R)-5,6-dihydro-2H-pyran-2-one has slightly better cytotoxicity than (R)-goniothalamin. To clarify the effect of 2-naphthyl substituent additional aryl substituted (R)-5,6-dihydro-2H-pyran-2-ones have been synthesized enantioselectively and tested against PC-3 and MCF-7 cell lines.en_US
dc.description.sponsorshipTUBITAK (105T429)en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.bmc.2008.10.069en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject(R)-Goniothalaminen_US
dc.subjectCancer cell linesen_US
dc.subjectConformationally constrained analoguesen_US
dc.subjectCytotoxic activityen_US
dc.title6-Bicycloaryl substituted (S)- and (R)-5,6-dihydro-2H-pyran-2-ones: Asymmetric synthesis, and anti-proliferative propertiesen_US
dc.typearticleen_US
dc.contributor.authorIDTR110975en_US
dc.contributor.iztechauthorKasaplar, Pınar
dc.contributor.iztechauthorYılmazer, Özgür
dc.contributor.iztechauthorÇağır, Ali
dc.relation.journalBioorganic and Medicinal Chemistryen_US
dc.contributor.departmentIzmir Institute of Technology. Chemistryen_US
dc.identifier.volume17en_US
dc.identifier.issue1en_US
dc.identifier.startpage311en_US
dc.identifier.endpage318en_US
dc.identifier.wosWOS:000261909800031
dc.identifier.scopusSCOPUS:2-s2.0-57649200458
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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