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dc.contributor.advisorYıldız, Ümit Hakan
dc.contributor.advisorArslan Yıldız, Ahu
dc.contributor.authorYıldız, Büşra
dc.date.accessioned2019-07-11T11:20:59Z
dc.date.available2019-07-11T11:20:59Z
dc.date.issued2018-12en_US
dc.identifier.citationYıldız, B. (2018). Ultra-porous interconnected hydrogel structures for tissue engineering applications. Unpublished master's thesis, İzmir Institute of Technology, İzmir, Turkeyen_US
dc.identifier.urihttps://hdl.handle.net/11147/7162
dc.descriptionThesis (Master)--Izmir Institute of Technology, Chemistry, Izmir, 2018en_US
dc.descriptionIncludes bibliographical references (leaves: 48-59)en_US
dc.descriptionText in English; Abstract: Turkish and Englishen_US
dc.description.abstractTissue engineering aims to repair and regenerate tissue and organs with functional defects. The most significant developments in tissue engineering emerging as modification of the scaffold used to mimic native extracellular matrix (ECM) and support cell proliferation and differentiation. Hydrogel-based biomaterials are one of the most utilized materials as scaffold providing excellent chemical, physical/biophysical properties, high biocompatibility and functionality necessary for the applications in tissue engineering. In this study, Gelatin methacryloyl hydrogel (GelMA) and Gelatin-urethane hydrogels (GelatinK) are successfully synthesized as scaffold material for tissue engineering applications. Gelatin is modified with methacrylic anhydride for GelMA polymer and with 2-isocyanatoethly methacrylate for GelatinK polymer. The hydrogels of these two novel polymer are produced with photopolymerization reactions in aqueous media using Irgacure 2959 as redox initiator. Hydrogels are freeze-dried to remove solvent in the gel matrix and then they immersed in distilled water to reach equilibrium swelling ratio. The swelling capacity of GelMA hydrogels ranges between 1200 and 300% whereas GelatinK hydrogels has swelling capacity in between 1900-380%. Also, morphology of the hydrogels were investigated with Scanning Electron Microscopy (SEM). GelMA hydrogels has pore sizes between 142-14 µm while GelatinK hydrogels has between 160-56 µm pore sizes. The cell viability assay were also conducted using GelMA and GelatinK hydrogels. The results showed that both hydrogels provide high viability as compared to 2D control assay.en_US
dc.format.extentxi, 59 leavesen_US
dc.language.isoengen_US
dc.publisherIzmir Institute of Technologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHydrogelen_US
dc.subjectGelatin methacryloyl hydrogel (GelMA)en_US
dc.subjectTissue engineeringen_US
dc.subjectPhotopolymerizationen_US
dc.titleUltra-porous interconnected hydrogel structures for tissue engineering applicationsen_US
dc.title.alternativeDoku mühendisliği uygulamaları için birbirine bağlı aşırı gözenekli hidrojen yapılaren_US
dc.typemasterThesisen_US
dc.contributor.departmentIzmir Institute of Technology. Chemistryen_US
dc.relation.publicationcategoryTezen_US


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