We proposed and experimentally demonstrated a fast and simple technique to measure refractive index of liquids. A commercial Optical Time-Domain Reflectometer (OTDR) was implemented for interrogating sensor tips from a remote location. The system uses Fresnel reflected light from standard single mode fiber tips as sensing points without requiring any chemical coating, delicate fiber components, and/or sophisticated architecture at the sensor head. We reported new measurements of refractive indices of common solvents and solutions at both 1550 nm and 1625 nm. The precision of the proposed measurement system was found to be in the order of 10-4. The experimental results have been validated by the way of theoretical calculations.