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dc.contributor.authorHoro, İbrahim
dc.contributor.authorKocabaş, Fatma
dc.contributor.authorAlankuş Çalışkan, Özgen
dc.contributor.authorÖzgökçe, Fevzi
dc.contributor.authorKhan, İhlas A.
dc.contributor.authorBedir, Erdal
dc.date.accessioned2017-09-14T06:53:48Z
dc.date.available2017-09-14T06:53:48Z
dc.date.issued2016
dc.identifier.citationHoro, İ., Kocabaş, F., Alankuş Çalışkan, Ö., Özgökçe, F., Khan, İ. A., and Bedir, E. (2016). Secondary metabolites from astragalus lycius and their cytotoxic activities. Natural Product Communications, 11(12), 1847-1850.en_US
dc.identifier.issn1934-578X
dc.identifier.urihttp://hdl.handle.net/11147/6262
dc.description.abstractEight known secondary metabolites were isolated from the methanolic extract of the whole plant of Astragalus lycius Boiss. They were identified as 5,5'-dihydroxy-3'-methoxy-isoflavone-7-O-β-D-glucoside (1), genistin (2), sissotrin (3), 5,4'-dimethoxy-isoflavone-7-O-β-D-glucopyranoside (4), (7S,8R)-5-methoxydehydrodiconiferyl alcohol-4-O-β-D-glucopyranoside (5), 4-O-lariciresinol-glucoside (6), 2-phenylethyl-β-D-glucopyranoside (7) and β-sitosterol-3-O-β-D-glucopyranoside (8) by spectroscopic methods including 1H- and 13C-NMR and HR-MS experiments, and by comparison with literature values. Compounds 1-7 are reported for the first time from Astragalus taxa. All of the compounds were tested for their cytotoxic activities against a number of cancer cell lines. Among them, only 6 exhibited significant activity against human colon carcinoma (HT-29) at 2.69 μM concentration.en_US
dc.description.sponsorshipTUBITAK (109T425); Ege University Research Foundation (2009 Fen 090); EBILTEM (2010/BIL/008)en_US
dc.language.isoengen_US
dc.publisherNatural Product Incorporationen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAstragalus lyciusen_US
dc.subjectCytotoxic activityen_US
dc.subjectChemotaxanomyen_US
dc.subjectIsoflavoneen_US
dc.subjectCanceren_US
dc.subjectLignanen_US
dc.titleSecondary metabolites from astragalus lycius and their cytotoxic activitiesen_US
dc.typearticleen_US
dc.contributor.iztechauthorKocabaş, Fatma
dc.relation.journalNatural Product Communicationsen_US
dc.contributor.departmentİYTE, Mühendislik Fakültesi, Biyomühendislik Bölümüen_US
dc.identifier.volume11en_US
dc.identifier.issue12en_US
dc.identifier.startpage1847en_US
dc.identifier.endpage1850en_US
dc.identifier.wosWOS:000390975600018
dc.identifier.scopusSCOPUS:2-s2.0-85013367880


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