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dc.contributor.authorJudex, Stefan
dc.contributor.authorZhang, Weidong
dc.contributor.authorDonahue, Leah Rae
dc.contributor.authorÖzçivici, Engin
dc.date.accessioned2017-08-25T08:07:30Z
dc.date.available2017-08-25T08:07:30Z
dc.date.issued2016-09
dc.identifier.citationJudex, S., Zhang, W., Donahue, L. R., and Özçivici, E. (2016). Genetic and tissue level muscle-bone interactions during unloading and reambulation. Journal of Musculoskeletal Neuronal Interactions, 16(3), 174-182.en_US
dc.identifier.issn1108-7161
dc.identifier.urihttp://hdl.handle.net/11147/6181
dc.description.abstractLittle is known about interactions between muscle and bone during the removal and application of mechanical signals. Here, we applied 3wk of hindlimb unloading followed by 3wk of reambulation to a genetically heterogeneous population of 352 adult mice and tested the hypothesis that changes in muscle are associated with changes in bone at the level of the tissue and the genome. During unloading and relative to normally ambulating control mice, most mice lost muscle and cortical bone with large variability across the population. During reambulation, individual mice regained bone and muscle at different rates. Across mice, changes in muscle and trabecular/cortical bone were not correlated to each other during unloading or reambulation. For unloading, we found one significant quantitative trait locus (QTL) for muscle area and five QTLs for cortical bone without overlap between mechano-sensitive muscle and cortical bone QTLs (but some overlap between muscle and trabecular QTLs). The low correlations between morphological changes in muscle and bone, together with the largely distinct genetic regulation of the response indicate that the premise of a muscle-bone unit that co-adjusts its size during (un)loading may need to be reassessed. © 2016, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.en_US
dc.description.sponsorshipNASA (NAG 9-1499 -- NNX-12AL25G)en_US
dc.language.isoengen_US
dc.publisherInternational Society of Musculoskeletal and Neuronal Interactionsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBoneen_US
dc.subjectDisuseen_US
dc.subjectGenetic regulationen_US
dc.subjectTissue levelen_US
dc.titleGenetic and tissue level muscle-bone interactions during unloading and reambulationen_US
dc.typearticleen_US
dc.contributor.authorIDTR30296en_US
dc.contributor.iztechauthorÖzçivici, Engin
dc.relation.journalJournal of Musculoskeletal Neuronal Interactionsen_US
dc.contributor.departmentIzmir Institute of Technology. Biotechnology and Bioengineeringen_US
dc.identifier.volume16en_US
dc.identifier.issue3en_US
dc.identifier.startpage174en_US
dc.identifier.endpage182en_US
dc.identifier.wosWOS:000385022800001
dc.identifier.scopusSCOPUS:2-s2.0-84991384655
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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