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dc.contributor.authorDoty, Richard L.
dc.contributor.authorTourbier, Isabelle A.
dc.contributor.authorPham, Dzung L.
dc.contributor.authorCuzzocreo, Jennifer L.
dc.contributor.authorUdupa, Jayaram K.
dc.contributor.authorKaraçalı, Bilge
dc.contributor.authorBeals, Evan
dc.contributor.authorFabius, Laura
dc.contributor.authorLeon-Sarmiento, Fidias E.
dc.contributor.authorMoonis, Gul
dc.contributor.authorKim, Taehoon
dc.contributor.authorMihama, Toru
dc.contributor.authorGeckle, Rena J.
dc.contributor.authorYousem, David M.
dc.date.accessioned2017-08-18T07:58:36Z
dc.date.available2017-08-18T07:58:36Z
dc.date.issued2016-04
dc.identifier.citationDoty, R. L., Tourbier, I. A., Pham, D. L., Cuzzocreo, J. L., Udupa, J. K., Karaçalı, B., Beals, E., ...Yousem, D. M. (2016). Taste dysfunction in multiple sclerosis. Journal of Neurology, 263(4), 677-688. doi:10.1007/s00415-016-8030-6en_US
dc.identifier.issn0340-5354
dc.identifier.urihttp://doi.org/10.1007/s00415-016-8030-6
dc.identifier.urihttp://hdl.handle.net/11147/6152
dc.description.abstractEmpirical studies of taste function in multiple sclerosis (MS) are rare. Moreover, a detailed assessment of whether quantitative measures of taste function correlate with the punctate and patchy myelin-related lesions found throughout the CNS of MS patients has not been made. We administered a 96-trial test of sweet (sucrose), sour (citric acid), bitter (caffeine) and salty (NaCl) taste perception to the left and right anterior (CN VII) and posterior (CN IX) tongue regions of 73 MS patients and 73 matched controls. The number and volume of lesions were assessed using quantitative MRI in 52 brain regions of 63 of the MS patients. Taste identification scores were significantly lower in the MS patients for sucrose (p = 0.0002), citric acid (p = 0.0001), caffeine (p = 0.0372) and NaCl (p = 0.0004) and were present in both anterior and posterior tongue regions. The percent of MS patients with identification scores falling below the 5th percentile of controls was 15.07 % for caffeine, 21.9 % for citric acid, 24.66 % for sucrose, and 31.50 % for NaCl. Such scores were inversely correlated with lesion volumes in the temporal, medial frontal, and superior frontal lobes, and with the number of lesions in the left and right superior frontal lobes, right anterior cingulate gyrus, and left parietal operculum. Regardless of the subject group, women outperformed men on the taste measures. These findings indicate that a sizable number of MS patients exhibit taste deficits that are associated with MS-related lesions throughout the brain.en_US
dc.description.sponsorshipU.S. National Institutes of Health ( RO1 DC 02974 -- R01 NS 37172 -- R01 NS070906)en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s00415-016-8030-6en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChemosensory transductionen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectMultiple sclerosisen_US
dc.subjectSex differencesen_US
dc.subjectTaste disordersen_US
dc.titleTaste dysfunction in multiple sclerosisen_US
dc.typearticleen_US
dc.contributor.authorIDTR11527en_US
dc.contributor.iztechauthorKaraçalı, Bilge
dc.relation.journalJournal of Neurologyen_US
dc.contributor.departmentİYTE, Mühendislik Fakültesi, Elektrik-Elektronik Mühendisliği Bölümüen_US
dc.identifier.volume263en_US
dc.identifier.issue4en_US
dc.identifier.startpage677en_US
dc.identifier.endpage688en_US
dc.identifier.wosWOS:000373742600007
dc.identifier.scopusSCOPUS:2-s2.0-84955316821
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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