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dc.contributor.advisorArtok, Leventen_US
dc.contributor.authorAytaç, İsmet Arınç
dc.date.accessioned2017-06-06T08:03:35Z
dc.date.available2017-06-06T08:03:35Z
dc.date.issued2016-10
dc.identifier.citationAytaç, İ. A. (2016). Coupling reactions of enyne oxiranes with grignard reagents. Unpublished master's thesis, İzmir Institute of Technology, İzmir, Turkeyen_US
dc.identifier.urihttp://hdl.handle.net/11147/5700
dc.descriptionThesis (Master)--İzmir Institute of Technology, Chemistry, İzmir, 2016en_US
dc.descriptionIncludes bibliographical references (leaves: 68-73)en_US
dc.descriptionText in English; Abstract: Turkish and Englishen_US
dc.descriptionxii, 195 leavesen_US
dc.description.abstractLaboratory-synthesized (Z)-2,4-Enyne oxiranes were subjected iron-catalyzed reactions with Grignard reagents. The reactions afforded majorly E-configured vinylallenes with a hydroxyl group on the allylic carbon as the 1,5-(SN2'')-substitution products. However, in some case, along with the desired vinyllallenes products, 1,1- (SN2) and 1,3-substitution (SN2’) by-products were also recovered. Diastereo-selectivity of the method is strictly reliant on the syn/anti mode of the alkylation process. This study provides a new methodology for the synthesis of vinylallenes which are potential building blocks of biological active molecules.en_US
dc.description.abstractLaboratuvarda sentezlenen (Z)-2,4-enin oksiran bileşiklerinin Grignard reaktifleri ile demir katalizli tepkimeleri gerçekleştirilmiştir. Bu tepkimeler ana ürün olarak 1,5-(SN2”)-sübstitüsyon ürünü olan E-konfigürasyona sahip allilik pozisyonunda hidroksil grubu bulunan vinilallen ürünleri vermektedir. 1,1-(SN2) ve 1,3-(SN2) ürünleri de bazı reaktiflerin tepkimelerinde oluşabilmektedir. Tepkimenin diastereo seçimliliği alkilasyonun yalnızca syn ya da anti modunda gerçekleşmesine bağlıdır. Bu çalışma, biyolojik olarak aktif moleküllerin çeşitli yapı taşları olabilecek vinylallen sentezi için yeni bir yöntem sunmaktadır.en_US
dc.description.sponsorshipTUBITAK-113Z155en_US
dc.language.isoengen_US
dc.publisherİzmir Institute of Technologyen_US
dc.relationinfo:eu-repo/grantAgreement/TUBITAK/KBAG/113Z155en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOrganic chemistryen_US
dc.subjectGrignard reactionen_US
dc.subjectIron catalysisen_US
dc.subjectEnyne oxiranesen_US
dc.titleCoupling reactions of enyne oxiranes with Grignard reagentsen_US
dc.title.alternativeEnin oksiranların Grignard reaktifleri ile kenetlenme tepkimelerien_US
dc.typemasterThesisen_US
dc.contributor.departmentİzmir Institute of Technology. Chemistryen_US
dc.relation.publicationcategoryTezen_US


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