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dc.contributor.authorSaçar, Müşerref Duygu
dc.contributor.authorAllmer, Jens
dc.date.accessioned2017-05-30T10:48:10Z
dc.date.available2017-05-30T10:48:10Z
dc.date.issued2014
dc.identifier.citationSaçar, M. D., and Allmer, J. (2014). Machine learning methods for microRNA gene prediction. Methods in Molecular Biology, 1107, 177-187. doi:10.1007/978-1-62703-748-8-10en_US
dc.identifier.issn1064-3745
dc.identifier.urihttp://hdl.handle.net/11147/5643
dc.identifier.urihttp://doi.org/10.1007/978-1-62703-748-8_10
dc.description.abstractMicroRNAs (miRNAs) are single-stranded, small, noncoding RNAs of about 22 nucleotides in length, which control gene expression at the posttranscriptional level through translational inhibition, degradation, adenylation, or destabilization of their target mRNAs. Although hundreds of miRNAs have been identified in various species, many more may still remain unknown. Therefore, discovery of new miRNA genes is an important step for understanding miRNA-mediated posttranscriptional regulation mechanisms. It seems that biological approaches to identify miRNA genes might be limited in their ability to detect rare miRNAs and are further limited to the tissues examined and the developmental stage of the organism under examination. These limitations have led to the development of sophisticated computational approaches attempting to identify possible miRNAs in silico. In this chapter, we discuss computational problems in miRNA prediction studies and review some of the many machine learning methods that have been tried to address the issues.en_US
dc.description.sponsorshipTurkish Academy of Sciencesen_US
dc.language.isoengen_US
dc.publisherHumana Pressen_US
dc.relation.isversionof10.1007/978-1-62703-748-8-10en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMicroRNAsen_US
dc.subjectArtificial intelligenceen_US
dc.subjectAlgorithmsen_US
dc.subjectGenesen_US
dc.subjectMachine learningen_US
dc.subjectClassificationen_US
dc.titleMachine learning methods for microRNA gene predictionen_US
dc.typearticleen_US
dc.typesubmittedVersion
dc.contributor.authorIDTR114170en_US
dc.contributor.authorIDTR107974en_US
dc.contributor.iztechauthorSaçar, Müşerref Duygu
dc.contributor.iztechauthorAllmer, Jens
dc.relation.journalMethods in Molecular Biologyen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume1107en_US
dc.identifier.startpage177en_US
dc.identifier.endpage187en_US
dc.identifier.scopusSCOPUS:2-s2.0-84891774362


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