Show simple item record

dc.contributor.authorBarlas, F. B.
dc.contributor.authorAğ Şeleci, D.
dc.contributor.authorÖzkan, M.
dc.contributor.authorDemir, B.
dc.contributor.authorŞeleci, M.
dc.contributor.authorAydın, M.
dc.contributor.authorTaşdelen, M. A.
dc.contributor.authorZareie, Hadi M.
dc.contributor.authorTimur, S.
dc.contributor.authorÖzçelik, Serdar
dc.contributor.authorYağcı, Y.
dc.date.accessioned2017-04-28T07:38:08Z
dc.date.available2017-04-28T07:38:08Z
dc.date.issued2014-10
dc.identifier.citationBarlas, F. B., Ağ Şeleci, D., Özkan, M., Demir, B., Şeleci, M., Aydın, M., Taşdelen, M. A., Zareie, H. M., Timur, S., Özçelik, S. and Yağcı, Y. (2014). Folic acid modified clay/polymer nanocomposites for selective cell adhesion. Journal of Materials Chemistry B, 2(37), 6412-6421. doi:10.1039/c4tb00850ben_US
dc.identifier.issn2050-7518
dc.identifier.urihttp://doi.org/10.1039/c4tb00850b
dc.identifier.urihttp://hdl.handle.net/11147/5431
dc.description.abstractA folic acid (FA) modified poly(epsilon-caprolactone)/clay nanocomposite (PCL/MMT-(CH2CH2OH)2-FA) resulting in selective cell adhesion and proliferation was synthesized and characterized as a cell culture and biosensing platform. For this purpose, first the FA modified clay (MMT-(CH2CH2OH)2-FA) was prepared by treating the organo-modified clay, Cloisite 30B [MMT-(CH2CH 2OH)2] with FA in chloroform at 60°C. Subsequent ring opening polymerization of ε-caprolactone in the presence of tin octoate (Sn(Oct)2) using MMT-(CH2CH2OH)2-FA at 110°C resulted in the formation of MMT-(CH2CH 2OH)2-FA with an exfoliated clay structure. The structures of intermediates and the final nanocomposite were investigated in detail by FT-IR spectral analysis and DSC, TGA, XRD, SEM and AFM measurements. The combination of FA, PCL and clay provides a simple and versatile route to surfaces that allows controlled and selective cell adhesion and proliferation. FA receptor-positive HeLa and negative A549 cells were used to prove the selectivity of the modified surfaces. Both microscopy and electrochemical sensing techniques were applied to show the differences in cell adherence on the modified and pristine clay platforms. This approach is expected to be adapted into various bio-applications such as 'cell culture on chip', biosensors and design of tools for targeted diagnosis or therapy.en_US
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionof10.1039/c4tb00850ben_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClaysen_US
dc.subjectPolymersen_US
dc.subjectNanocompositesen_US
dc.subjectFolic aciden_US
dc.subjectCell adhesionen_US
dc.subjectBiomedical researchen_US
dc.titleFolic acid modified clay/polymer nanocomposites for selective cell adhesionen_US
dc.typearticleen_US
dc.contributor.authorIDTR7497en_US
dc.contributor.iztechauthorÖzkan, M.
dc.contributor.iztechauthorZareie, Hadi M.
dc.contributor.iztechauthorÖzçelik, Serdar
dc.relation.journalJournal of Materials Chemistry Ben_US
dc.contributor.departmentİYTE, Fen Fakültesi, Kimya Bölümüen_US
dc.identifier.volume2en_US
dc.identifier.issue37en_US
dc.identifier.startpage6412en_US
dc.identifier.endpage6421en_US
dc.identifier.wosWOS:000341457500028
dc.identifier.scopusSCOPUS:2-s2.0-84907076930
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record