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dc.contributor.authorÇinçin, Zeynep Birsu
dc.contributor.authorÜnlü, Miray
dc.contributor.authorKıran, Bayram
dc.contributor.authorBireller, Elif Sinem
dc.contributor.authorBaran, Yusuf
dc.contributor.authorÇakmakoğlu, Bedia
dc.date.accessioned2017-04-27T07:28:07Z
dc.date.available2017-04-27T07:28:07Z
dc.date.issued2014-08
dc.identifier.citationÇinÇin, Z.B., Ünlü, M., Kıran, B., Bireller, E.S., Baran, Y., and Çakmakoğlu, B. (2014). Apoptotic effects of quercitrin on DLD-1 colon cancer cell line. Pathology and Oncology Research, 21(2), 333-338. doi:10.1007/s12253-014-9825-3en_US
dc.identifier.issn1219-4956
dc.identifier.urihttps://doi.org/10.1007/s12253-014-9825-3
dc.identifier.urihttp://hdl.handle.net/11147/5417
dc.description.abstractQuercetin, which is the most abundant bioflavonoid compound, is mainly present in the glycoside form of quercitrin. Although different studies indicated that quercitrin is a potent antioxidant, the action of this compound is not well understood. In this study, we investigated whether quercitrin has apoptotic and antiproliferative effects in DLD-1 colon cancer cell lines. Time and dose dependent antiproliferative and apoptotic effects of quercitrin were subsequently determined by WST-1 cell proliferation assay, lactate dehydrogenase (LDH) cytotoxicity assay, detection of nucleosome enrichment factor, changes in caspase-3 activity, loss of mitochondrial membrane potential (MMP) and also the localization of phosphatidylserine (PS) in the plasma membrane. There were significant increases in caspase-3 activity, loss of MMP, and increases in the apoptotic cell population in response to quercitrin in DLD-1 colon cancer cells in a time- and dose-dependent manner. These results revealed that quercitrin has antiproliferative and apoptotic effects on colon cancer cells. Quercitrin activity supported with in vivo analyses could be a biomarker candicate for early colorectal carcinoma.en_US
dc.description.sponsorshipIstanbul University Scientific Research Projects (31162)en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s12253-014-9825-3en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntiproliferativeen_US
dc.subjectApoptosisen_US
dc.subjectQuercitrinen_US
dc.subjectColon canceren_US
dc.subjectAntineoplastic agenten_US
dc.titleApoptotic effects of quercitrin on DLD-1 colon cancer cell lineen_US
dc.typearticleen_US
dc.contributor.authorIDTR119193en_US
dc.contributor.iztechauthorÜnlü, Miray
dc.contributor.iztechauthorBaran, Yusuf
dc.relation.journalPathology and Oncology Researchen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume21en_US
dc.identifier.issue2en_US
dc.identifier.startpage333en_US
dc.identifier.endpage338en_US
dc.identifier.wosWOS:000354265700013
dc.identifier.scopusSCOPUS:2-s2.0-84938214197
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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