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dc.contributor.authorYaşar Mahlıçlı, Filiz
dc.contributor.authorAlsoy Altınkaya, Sacide
dc.date.accessioned2017-04-19T08:02:45Z
dc.date.available2017-04-19T08:02:45Z
dc.date.issued2013-02
dc.identifier.citationYaşar Mahlıçlı, F., and Alsoy Altınkaya, S. (2013). Surface modification of polysulfone based hemodialysis membranes with layer by layer self assembly of polyethyleneimine/alginate-heparin: A simple polyelectrolyte blend approach for heparin immobilization. Journal of Materials Science: Materials in Medicine, 24(2), 533-546. doi:10.1007/s10856-012-4804-2en_US
dc.identifier.issn0957-4530
dc.identifier.urihttps://doi.org/10.1007/s10856-012-4804-2
dc.identifier.urihttp://hdl.handle.net/11147/5345
dc.description.abstractThis study intends to improve blood compatibility of polysulfone (PSF) membranes by generating a nonthrombogenic surface through heparin immobilization. To achieve this task, the support membrane prepared from a blend of PSF and sulfonated polysulfone (SPSF) was modified with layer by layer (LBL) deposition of polyethyleneimine (PEI) and alginate (ALG) and heparin blended with ALG was immobilized only on the outermost surface of the LBL assembly. The results have shown that the adsorption of human plasma proteins and platelet activation on the LBL modified membranes decreased significantly compared with the unmodified PSF and PSF-SPSF blend membranes. Furthermore, blending ALG with a small amount of heparin remarkably prolonged the APTT values of heparin free PEI/ALG coated membranes. It is envisaged that the use of a blend of HEP and ALG only in the terminating layer of the LBL assembly can be an economical and alternative modification technique to create nonthrombogenic surfaces.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s10856-012-4804-2en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBlood compatibilityen_US
dc.subjectHemodialysis membranesen_US
dc.subjectHeparin immobilizationen_US
dc.subjectSulfonated polysulfoneen_US
dc.subjectHuman plasma proteinsen_US
dc.subjectMembraneen_US
dc.titleSurface modification of polysulfone based hemodialysis membranes with layer by layer self assembly of polyethyleneimine/alginate-heparin: A simple polyelectrolyte blend approach for heparin immobilizationen_US
dc.typearticleen_US
dc.contributor.authorIDTR2091en_US
dc.contributor.iztechauthorYaşar Mahlıçlı, Filiz
dc.contributor.iztechauthorAlsoy Altınkaya, Sacide
dc.relation.journalJournal of Materials Science: Materials in Medicineen_US
dc.contributor.departmentİYTE, Mühendislik Fakültesi, Kimya Mühendisliği Bölümüen_US
dc.identifier.volume24en_US
dc.identifier.issue2en_US
dc.identifier.startpage533en_US
dc.identifier.endpage546en_US
dc.identifier.wosWOS:000314775100024
dc.identifier.scopusSCOPUS:2-s2.0-84878368067
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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