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dc.contributor.authorCan, Geylani
dc.contributor.authorEkiz, Hüseyin Atakan
dc.contributor.authorBaran, Yusuf
dc.date.accessioned2017-03-20T11:56:51Z
dc.date.available2017-03-20T11:56:51Z
dc.date.issued2011-03
dc.identifier.citationCan, G., Ekiz, H.A., and Baran, Y. (2011). Imatinib induces autophagy through BECLIN-1 and ATG5 genes in chronic myeloid leukemia cells. Hematology, 16(2), 95-99. doi:10.1179/102453311X12902908412039en_US
dc.identifier.issn1024-5332
dc.identifier.urihttps://doi.org/10.1179/102453311X12902908412039
dc.identifier.urihttp://hdl.handle.net/11147/5101
dc.description.abstractLocate full-text(opens in a new window)|Full Text(opens in a new window)|View at Publisher| Export | Download | Add to List | More... Hematology Volume 16, Issue 2, March 2011, Pages 95-99 Imatinib induces autophagy through BECLIN-1 and ATG5 genes in chronic myeloid leukemia cells (Article) Can, G., Ekiz, H.A., Baran, Y. Department of Molecular Biology and Genetics, Faculty of Science, Izmir Institute of Technology, 35430 Urla, Izmir, Turkey View references (35) Abstract Imatinib is a chemotherapeutic drug used for the treatment of chronic myeloid leukemia (CML). Recent data showed imatinib-induced cell death in various types of cancers. Autophagy is the physiological process in which cellular components are broken down by the lysosomal activation. In this study, we aimed to examine the effects of imatinib on autophagy in addition to apoptosis in CML cells. Results suggested that imatinib induces autophagy in CML cells through inducing over-expression of BECLIN-1 and ATG5 genes with the statistical significance. Our results demonstrated that autophagy might be involved in imatinib-induced cell death.en_US
dc.description.sponsorshipTurkish Academy of Sciencesen_US
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.isversionof10.1179/102453311X12902908412039en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectATG genesen_US
dc.subjectAutophagyen_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectImatiniben_US
dc.subjectBECLIN 1 geneen_US
dc.titleImatinib induces autophagy through BECLIN-1 and ATG5 genes in chronic myeloid leukemia cellsen_US
dc.typearticleen_US
dc.contributor.authorIDTR119193en_US
dc.contributor.iztechauthorCan, Geylani
dc.contributor.iztechauthorEkiz, Hüseyin Atakan
dc.contributor.iztechauthorBaran, Yusuf
dc.relation.journalHematologyen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume16en_US
dc.identifier.issue2en_US
dc.identifier.startpage95en_US
dc.identifier.endpage99en_US
dc.identifier.wosWOS:000288594400006
dc.identifier.scopusSCOPUS:2-s2.0-79952690221
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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