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dc.contributor.authorMutlu, Pelin
dc.contributor.authorBaran, Yusuf
dc.contributor.authorUral, Ali Uǧur
dc.contributor.authorAvcu, Ferit
dc.contributor.authorDirican, Bahar
dc.contributor.authorBeyzadeoǧlu, Murat
dc.contributor.authorGündüz, Ufuk
dc.date.accessioned2017-03-15T06:41:05Z
dc.date.available2017-03-15T06:41:05Z
dc.date.issued2011-07
dc.identifier.citationMutlu, P., Baran, Y., Ural, A.U., Avcu, F., Dirican, B., Beyzadeoğlu, M., and Gündüz, U. (2011). Effect of cobalt-60 (γ radiation) on multidrug-resistant multiple myeloma cell lines. Cell Biology International, 35(7), 721-725. doi:10.1042/CBI20100061en_US
dc.identifier.issn1065-6995
dc.identifier.urihttp://doi.org/10.1042/CBI20100061
dc.identifier.urihttp://hdl.handle.net/11147/5054
dc.description.abstractEmergence of resistance to chemotherapy and radiotherapy is a major obstacle for the successful treatment of MM (multiple myeloma). Prednisone, vincristine and melphalan are commonly used chemotherapeutic agents for the treatment of MM. In the current study, we examined the presence of possible cross-resistance between these drugs and gamma (γ) radiation. Prednisone, vincristine and melphalan resistant RPMI-8226 and U-266 MM cells were generated by stepwise increasing concentrations of the drugs. The sensitive and resistant cells were exposed to 200- and 800 cGy c radiation, and proliferation was examined by XTT {2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-t etrazolium hydroxide} assay. The results showed that Prednisone- and melphalan-resistant RPMI-8226 cells were also cross-resistant to 200 and 800 cGy γ radiation application, while vincristine-resistant cells did not show resistance. On the other hand, Prednisone-, vincristine- and melphalan-resistant U-266 cells showed cross-resistance to 200- and 800 cGy c radiation application. These results demonstrated that MM cells resistant to anticancer agents respond to radiation in different levels. These findings may be important in the clinical applications of radiation therapy in the treatment of vincristine resistant MM. © The Author(s) Journal compilationen_US
dc.description.sponsorshipTUBITAK grant number SBAG 3297en_US
dc.language.isoengen_US
dc.publisherPortland Pressen_US
dc.relationinfo:eu-repo/grantAgreement/TUBITAK/SBAG/3297en_US
dc.relation.isversionof10.1042/CBI20100061en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDrug resistanceen_US
dc.subjectMultiple myelomaen_US
dc.subjectRadioresistanceen_US
dc.subjectRPMI-8226en_US
dc.subjectU-266en_US
dc.titleEffect of cobalt-60 (γ radiation) on multidrug-resistant multiple myeloma cell linesen_US
dc.typearticleen_US
dc.contributor.authorIDTR119193en_US
dc.contributor.iztechauthorBaran, Yusuf
dc.relation.journalCell Biology Internationalen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume35en_US
dc.identifier.issue7en_US
dc.identifier.startpage721en_US
dc.identifier.endpage725en_US
dc.identifier.wosWOS:000293990800010
dc.identifier.scopusSCOPUS:2-s2.0-79959295983
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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