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dc.contributor.authorAvcı, Çığır Biray
dc.contributor.authorYılmaz, Sunde
dc.contributor.authorDoğan, Zeynep Özlem
dc.contributor.authorSaydam, Güray
dc.contributor.authorDodurga, Yavuz
dc.contributor.authorEkiz, Hüseyin Atakan
dc.contributor.authorKartal, Melis
dc.contributor.authorŞahin, Fahri
dc.contributor.authorBaran, Yusuf
dc.contributor.authorGündüz, Cumhur
dc.date.accessioned2017-03-02T10:34:40Z
dc.date.available2017-03-02T10:34:40Z
dc.date.issued2011-09
dc.identifier.citationAvcı, Ç. B., Yılmaz, S., Doğan, Z.Ö., Saydam, G., Dodurga, Y., Ekiz, H. A., Kartal, M., Şahin, F., Baran, Y., and Gündüz, C. (2011). Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells. Hematology, 16(6) , 303-307. doi:10.1179/102453311X13085644680104en_US
dc.identifier.issn1024-5332
dc.identifier.urihttp://doi.org/10.1179/102453311X13085644680104
dc.identifier.urihttp://hdl.handle.net/11147/4950
dc.description.abstractWe aimed to examine the growth suppressive effects of quercetin on acute promyelocytic and lymphoblastic leukemia and chronic myeloid leukemia, and to find out whether the growth suppression is related to the blocking of telomerase enzyme activity. Cytotoxic effects of quercetin were shown by trypan blue analyses. Apoptotic effects of quercetin were examined by acridine orange and ethidium bromide staining by fluorescence microscopy. The effects of quercetin on telomerase enzyme activity were shown by hTERT Quantification Kit. Our results demonstrated that quercetin has antiproliferative and apoptotic effects on T-cell acute lymphoblastic leukemia (ALL), acute promyelocytic leukemia, and chronic myeloid leukemia (CML) cells. We also showed for the first time by this study that quercetin suppresses the activity of telomerase in ALL and CML cells. The results of this study show the importance of quercetin for its therapeutic potential in treatment of leukemias.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.isversionof10.1179/102453311X13085644680104en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjecthTERTen_US
dc.subjectLeukemiaen_US
dc.subjectQuercetinen_US
dc.subjectTelomeraseen_US
dc.titleQuercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cellsen_US
dc.typearticleen_US
dc.contributor.authorIDTR119193en_US
dc.contributor.iztechauthorEkiz, Hüseyin Atakan
dc.contributor.iztechauthorKartal, Melis
dc.contributor.iztechauthorBaran, Yusuf
dc.relation.journalHematologyen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume16en_US
dc.identifier.issue5en_US
dc.identifier.startpage303en_US
dc.identifier.endpage307en_US
dc.identifier.wosWOS:000294495000008
dc.identifier.scopusSCOPUS:2-s2.0-80052590432
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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