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dc.contributor.authorJovanović, B.
dc.contributor.authorBaran, Ezgi
dc.contributor.authorGoetz, F. W.
dc.contributor.authorPalić, D.
dc.date.accessioned2017-03-01T08:03:38Z
dc.date.available2017-03-01T08:03:38Z
dc.date.issued2011-11
dc.identifier.citationJovanović, B., Baran, E., Goetz, F. W., and Palić, D. (2011). Effects of different lipopolysaccharide preparations on neutrophil function in the fathead minnow, Pimephales promelas Rafinesque. Journal of Fish Diseases, 34(11), 877-880. doi:10.1111/j.1365-2761.2011.01298.xen_US
dc.identifier.issn0140-7775
dc.identifier.urihttp://doi.org/10.1111/j.1365-2761.2011.01298.x
dc.identifier.urihttp://hdl.handle.net/11147/4932
dc.description.abstractThe fish innate immune response to pathogensrelies on the adequate function of neu trophilicgranulocytes (Palic´, Andreasen, Herolt, Menzel &Roth 2006). The ability of neutrophils to phago-cytose microor ganisms and cellular debris is essen-tial for normal development an d survival of animalpopulations (Segal 2005). The evaluation of neu-trophil function is valuable for assessing the healthstatus of individuals and fish populations (Smith &Lumsden 1983). Resistance of fishes to septic shockand tolerance to high concentrations of lipopoly-saccharide (LPS) was observed as a major differencebetween mammalian and fish innate immuneresponses (Berczi, Bertok & Bereznai 1966). Thisfunctional difference could be attri buted to severalcostimulatory molecules and intracellular mediatorsbeing absent in fish, but active in mammals duringresponse to LPS stimulation (Iliev, Roach, Mac-kenzie, Planas & Goetz 2005). Most fish do notpossess a Toll-like receptor (TLR) with sequencesimilarity to mammalian TLR4 (Leulier & Lemai-tre 2008) and the ones that do have no ability forTLR4 downstream signalling (Sepulcre, Alcaraz-Perez, Lopez-Munoz, Roca, Meseguer, Cayuela &Mulero 2009). Regardless of the absence andfunctionality of TLR4 and costimulatory molecules,bacterial LPS can induce a robus t inflammatorygene response in innate immune fish cells, but atconcentrations 1000-fold higher than is commonlyobserved in mammalian species ( lgmL)1vs.ng mL)1) (Palic´, Ostojic, Andreasen & Roth2007; Mackenzie, Roher, Boltan˜a & Goetz 2010).In contrast, ultrapure LPS preparations are rela-tively inactive in fish (Iliev et al. 2005).en_US
dc.language.isoengen_US
dc.publisherWiley-Blackwellen_US
dc.relation.isversionof10.1111/j.1365-2761.2011.01298.xen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCrude lipopolysaccharideen_US
dc.subjectImmunologyen_US
dc.subjectNeutrophil functionen_US
dc.subjectPeptidoglycansen_US
dc.titleEffects of different lipopolysaccharide preparations on neutrophil function in the fathead minnow, Pimephales promelas Rafinesqueen_US
dc.typearticleen_US
dc.contributor.iztechauthorBaran, Ezgi
dc.relation.journalJournal of Fish Diseasesen_US
dc.contributor.departmentIzmir Institute of Technology. Biotechnology and Bioengineering Research and Application Center (IZTECH BIYOMER)en_US
dc.identifier.volume34en_US
dc.identifier.issue11en_US
dc.identifier.startpage877en_US
dc.identifier.endpage880en_US
dc.identifier.wosWOS:000296258100007
dc.identifier.scopusSCOPUS:2-s2.0-80054012629


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