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Cholesterol Dictates the Freedom of EGF Receptors and HER2 in the Plane of the Membrane
The flow of information through the epidermal growth factor receptor (EGFR) is shaped by molecular interactions in the plasma membrane. The EGFR is associated with lipid rafts, but their role in modulating receptor mobility ...
FRET measurements between small numbers of molecules identifies subtle changes in receptor interactions
Overexpression of HER2 alters the cellular behavior of EGF receptor (EGFR) and itself,with great implications on cell fate. To understand the molecular interactions underlying these alterations, we quantified the association ...