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dc.contributor.advisorŞanli Mohamed, Gülşahen
dc.contributor.authorZeybek, Ayçaen
dc.date.accessioned2014-07-22T13:51:44Z
dc.date.available2014-07-22T13:51:44Z
dc.date.issued2012en
dc.identifier.urihttp://hdl.handle.net/11147/3529
dc.descriptionThesis (Master)--İzmir Institute of Technology, Chemistry, İzmir, 2012en
dc.descriptionIncludes bibliographical references (leaves: 46-51)en
dc.descriptionText in English; Abstract: Turkish and Englishen
dc.descriptionix, 57 leavesen
dc.description.abstractChemotherapy is a major therapeutic approach for treatment of a wide range of cancers. But unfortunately, this therapeutic approach has got a lot of side effects on healthy tissues as well as cancerous cells. Although doxorubicin is one of the most potent and widely used anticancer drugs, it has some side effects on healthy tissues, as well. Therefore, most researchers have studied various doxorubicin carrier systems for targeted delivery. For this purpose, doxorubicin loaded magnetic albumin nanospheres (M-DOX-BSA-NPs) were synthesized. The main objective of this project was basically to determine the cytotoxic, apoptotic and cell cycle effects of BSA-NPs, M-BSA-NPs, DOX, BSA-DOX-NPs and M-DOX-BSA-NPs against prostate and lung cancer cells and compare them. Beside this, it is aimed to understand how cells look like before and after giving doxorubicin and M-DOX-BSA-NPs by using optical microscopy and compare them. Another objective of this project was to determine where M-DOX-BSA-NPs reach out into the cell by using concofal microscopy; and to explore proteins’ differentiations between control groups and lung and prostate cancer cells in which DOX and M-DOX-BSA-NPs were applied, by proteomic studies. In this study, the experimental results which were also supported by literature findings, demonstrated that M-DOX-BSA-NPs were more toxic than free doxorubicin, and this complex was more effective for prostate cancer cells than lung cancer cells. As a result of this study, it was determined that this complex was synthesized as a target chemotherapy drug delivery system. Accordingly, this complex may affect to other cancer types, and it can be carried out by new drug designers and treatments.en
dc.language.isoengen
dc.publisherİzmir Institute of Technologyen
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject.lcshCancer cellsen
dc.subject.lcshAlbuminsen
dc.subject.lcshChemotherapyen
dc.subject.lcshNanoparticles--Magnetic propertiesen
dc.subject.lcshDoxorubicinen
dc.titleThe effect of doxorubicin-albumin magnetic nanoparticles on prostate and lung cancer cellsen
dc.typemasterThesisen
dc.contributor.departmentİzmir Institute of Technology. Chemistryen
dc.relation.publicationcategoryTezen_US


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