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dc.contributor.authorHacıoğlu, Elise
dc.contributor.authorEsmer, Işıl
dc.contributor.authorFomenko, Dmitri E.
dc.contributor.authorGladyshev, Vadim N.
dc.contributor.authorKoç, Ahmet
dc.date.accessioned2016-12-14T12:07:10Z
dc.date.available2016-12-14T12:07:10Z
dc.date.issued2010-11
dc.identifier.citationHacıoğlu, E., Esmer, I., Fomenko, D. E., Gladyshev, V. N., and Koç, A. (2010). The roles of thiol oxidoreductases in yeast replicative aging. Mechanisms of Ageing and Development, 131(11-12), 692-699. doi:10.1016/j.mad.2010.09.006en_US
dc.identifier.issn0047-6374
dc.identifier.urihttp://doi.org/10.1016/j.mad.2010.09.006
dc.identifier.urihttp://hdl.handle.net/11147/2623
dc.description.abstractThiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis. © 2010 Elsevier Ireland Ltd.en_US
dc.description.sponsorshipDPT-2003K120690; TÜBA-GEBİP and NIH AG021518en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.mad.2010.09.006en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectYeasten_US
dc.subjectOxidoreductaseen_US
dc.subjectOxidationen_US
dc.subjectLife spanen_US
dc.subjectAntioxidanten_US
dc.subjectAgingen_US
dc.titleThe roles of thiol oxidoreductases in yeast replicative agingen_US
dc.typearticleen_US
dc.contributor.authorIDTR115223en_US
dc.contributor.authorIDTR110769en_US
dc.contributor.iztechauthorHacıoğlu, Elise
dc.contributor.iztechauthorEsmer, Işıl
dc.contributor.iztechauthorKoç, Ahmet
dc.relation.journalMechanisms of Ageing and Developmenten_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume131en_US
dc.identifier.issue11-12en_US
dc.identifier.startpage692en_US
dc.identifier.endpage699en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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