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dc.contributor.authorAyhancı, Adnan
dc.contributor.authorYaman, Suzan
dc.contributor.authorAppak, Sıla
dc.contributor.authorGüneş, Sibel
dc.date.accessioned2016-11-11T13:40:43Z
dc.date.available2016-11-11T13:40:43Z
dc.date.issued2009-10
dc.identifier.citationAyhancı, A., Yaman, S., Appak, S., and Güneş, S. (2009). Hematoprotective effect of seleno-L-methionine on cyclophosphamide toxicity in rats. Drug and Chemical Toxicology, 32(4), 424-428. doi:10.1080/01480540903130682en_US
dc.identifier.issn0148-0545
dc.identifier.urihttp://dx.doi.org/10.1080/01480540903130682
dc.identifier.urihttp://hdl.handle.net/11147/2433
dc.description.abstractCyclophosphamide (CP) is a widely used antineoplastic drug that causes toxicity in the normal cell due to its metabolites. The major drawback of this drug is an undesirable myelosuppression. Selenium (Se) is a potent nutritional antioxidant that carries out biological effects by its incorporation into selenoproteins, such as glutathione peroxidase (GPx). The possible protective effects of seleno-l-methionine (SLM) against CP-related toxicity of blood cells and bone marrow of rats were investigated in this study. Intraperitoneal (i.p) administration of 50, 100, or 150mg/kg of CP caused, in a dose-dependent manner, reductions in the number of leukocytes (78, 89, and 92%, respectively), thrombocytes (22, 33, and 52%, respectively), and bone marrownucleated cells (72, 90, and 94%, respectively). The groups that had CP treatment alone were killed 3 days after the CP injection. For the groups having CPSLM, SLM (0.4 or 0.8mg/kg i.p) administration was started 3 days earlier than the CP administration and continued to the end of the experiment (6 days). On day 4, the animals were weighed again, relative doses of CP were estimated, and CPSLM was administered together. On day 7, blood samples were collected and bone marrow of animals were resected under anesthesia. The results indicated that treatment of rats within a select dose range of SLM could reduce CP-induced toxicity on blood cells and bone marrow.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.isversionof10.1080/01480540903130682en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCyclophosphamideen_US
dc.subjectCytoprotectivityen_US
dc.subjectHematoxicityen_US
dc.subjectSeleno-L-methionineen_US
dc.subjectRaten_US
dc.titleHematoprotective effect of seleno-L-methionine on cyclophosphamide toxicity in ratsen_US
dc.typearticleen_US
dc.contributor.iztechauthorAppak, Sıla
dc.relation.journalDrug and Chemical Toxicologyen_US
dc.contributor.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume32en_US
dc.identifier.issue4en_US
dc.identifier.startpage424en_US
dc.identifier.endpage428en_US
dc.identifier.wosWOS:000271745100017
dc.identifier.scopusSCOPUS:2-s2.0-74049114183
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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