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dc.contributor.authorKoç, Ahmet
dc.contributor.authorGladyshev, Vadim N.
dc.date.accessioned2016-10-18T12:01:19Z
dc.date.available2016-10-18T12:01:19Z
dc.date.issued2007-04
dc.identifier.citationKoç, A., and Gladyshev, V. N. (2007). Methionine sulfoxide reduction and the aging process. Annals of the New York Academy of Sciences, 1100, 383-386. doi:10.1196/annals.1395.042en_US
dc.identifier.issn0077-8923
dc.identifier.urihttp://doi.org/10.1196/annals.1395.042
dc.identifier.urihttp://hdl.handle.net/11147/2270
dc.description.abstractAging has been described for multicellular and asymmetrically dividing organisms, but the mechanisms are poorly understood. Oxidation of proteins is considered to be one of the major factors that leads to aging. Oxidative damage to proteins results in the oxidation of certain amino acid residues, among which oxidation of sulfur-containing amino acids, methionine and cysteine, is notable because of the susceptibility of these residues to damage, and occurrence of repair mechanisms. Methionine sulfoxide reductases, MsrA and MsrB, are thioredoxin-dependent oxidoreductases that reduce oxidized forms of methionine, methionine sulfoxides, in a stereospecific manner. These enzymes are present in all cell types and have shown to be regulating life spans in mammals, insects, and yeast. Here, their roles in modulating yeast life span are discussed.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1196/annals.1395.042en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgingen_US
dc.subjectAnaerobicen_US
dc.subjectMethionine sulfoxide reductaseen_US
dc.subjectYeast life spanen_US
dc.subjectReactive oxygen speciesen_US
dc.titleMethionine sulfoxide reduction and the aging processen_US
dc.typearticleen_US
dc.contributor.authorIDTR110769en_US
dc.contributor.iztechauthorKoç, Ahmet
dc.relation.journalAnnals of the New York Academy of Sciencesen_US
dc.contributor.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume1100en_US
dc.identifier.startpage383en_US
dc.identifier.endpage386en_US
dc.identifier.wosWOS:000246733700042
dc.identifier.scopusSCOPUS:2-s2.0-34249692347
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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