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dc.contributor.authorAltınkaya, Sacide
dc.contributor.authorYenal, Hacer
dc.date.accessioned2016-10-14T07:02:11Z
dc.date.available2016-10-14T07:02:11Z
dc.date.issued2006-02
dc.identifier.citationAltınkaya, S., and Yenal, H. (2006). In vitro drug release rates from asymmetric-membrane tablet coatings: Prediction of phase-inversion dynamics. Biochemical Engineering Journal, 28(2), 131-139. doi:10.1016/j.bej.2005.09.009en_US
dc.identifier.issn1369-703X
dc.identifier.urihttp://doi.org/10.1016/j.bej.2005.09.009
dc.identifier.urihttp://hdl.handle.net/11147/2238
dc.description.abstractMost of the controlled-release systems developed for drug delivery applications depend on membrane technology. The dense structure of some membranes used in controlled-release systems can excessively prolong the release of drug due to the low permeability of the coating to drug. To increase the drug release rate, asymmetric-membrane tablet coatings were prepared by a phase-inversion technique using cellulose acetate/acetone/water solution. The roles of the composition of the membrane solution and the evaporation condition on the release rate of drug were determined using in vitro dissolution and morphological studies and predicted phase diagrams. Results show that drug release from asymmetric-membrane based tablet coatings is primarily governed by the dynamics of the phase-inversion process with zero-order or near-zero-order release easily achievable. In an attempt to derive an empirical expression for the release rate of drug as a function of composition of the coating solution, a statistical experimental design was used. Good fit of the experimental data by the empirical expression was obtained. In addition, the predictive capability of the model equation was also found to be satisfactory. Analysis of the significance of each term in the expression indicates that the cellulose acetate:acetone ratio has the most significant influence on the release rate of theophylline.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.bej.2005.09.009en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDrug productsen_US
dc.subjectAsymmetric-membraneen_US
dc.subjectCellulose acetateen_US
dc.subjectPhase-inversionen_US
dc.subjectStatistical designen_US
dc.subjectTheophyllineen_US
dc.titleIn vitro drug release rates from asymmetric-membrane tablet coatings: Prediction of phase-inversion dynamicsen_US
dc.typearticleen_US
dc.contributor.authorIDTR2091en_US
dc.contributor.iztechauthorAltınkaya, Sacide
dc.contributor.iztechauthorYenal, Hacer
dc.relation.journalBiochemical Engineering Journalen_US
dc.contributor.departmentIzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume28en_US
dc.identifier.issue2en_US
dc.identifier.startpage131en_US
dc.identifier.endpage139en_US
dc.identifier.wosWOS:000235682700004
dc.identifier.scopusSCOPUS:2-s2.0-31944442499
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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