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dc.contributor.authorBaşoğlu, Harun
dc.contributor.authorBilgin, Mehmet Dinçer
dc.contributor.authorDemir, Mustafa M.
dc.date.accessioned2016-07-13T11:15:20Z
dc.date.available2016-07-13T11:15:20Z
dc.date.issued2016-03
dc.identifier.citationBaşoğlu, H., Bilgin, M. D., and Demir, M. M. (2016). Protoporphyrin IX-loaded magnetoliposomes as a potential drug delivery system for photodynamic therapy: Fabrication, characterization and in vitro study. Photodiagnosis and Photodynamic Therapy, 13, 81-90. doi:10.1016/j.pdpdt.2015.12.010en_US
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.pdpdt.2015.12.010
dc.identifier.urihttp://hdl.handle.net/11147/1893
dc.description.abstractProtoporphyrin IX (PpIX) is a well-known photosensitizer that has great potential for use in photodynamic therapy (PDT). However, aggregation behavior of PpIX in neutral water makes it inappropriate for physiological studies. PpIX-loaded magnetoliposomes (MLs) were fabricated to increase PpIX biocompatibility. PpIX-loaded ML physical properties were characterized, and PpIX-loaded ML drug release behavior was investigated under the influence of an external magnetic field and heat. Toxicity and photodynamic effects of the complex were also examined using in vitro experiments with MCF-7 human breast cancer cells. The magnetoliposomes were prepared with DPPC, DSPE-PEG2000 lipids and Fe3O4 nanoparticles. The toxicity and in vitro photodynamic effects of the PpIX-loaded MLs at various concentrations were studied using the MCF-7 cell line.en_US
dc.description.sponsorshipTÜBİTAk (grant no: 112S958); Adnan Menderes University (grant no: TPF-13014)en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.pdpdt.2015.12.010en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProtoporphyrin IXen_US
dc.subjectMagnetoliposomesen_US
dc.subjectIron oxide nanoparticlesen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectMCF-7 cellsen_US
dc.titleProtoporphyrin IX-loaded magnetoliposomes as a potential drug delivery system for photodynamic therapy: Fabrication, characterization and in vitro studyen_US
dc.typearticleen_US
dc.typeacceptedVersionen_US
dc.contributor.authorIDTR130614en_US
dc.contributor.iztechauthorDemir, Mustafa M.
dc.relation.journalPhotodiagnosis and Photodynamic Therapyen_US
dc.contributor.departmentIzmir Institute of Technology. Materials Science and Engineeringen_US
dc.identifier.volume13en_US
dc.identifier.startpage81en_US
dc.identifier.endpage90en_US
dc.identifier.wosWOS:000372376500013
dc.identifier.scopusSCOPUS:2-s2.0-84960473615
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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