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Browsing by Author "Köksal, Mustafa"
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1.55 Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis
Köksal, Mustafa; Potter, Kevin; Peters, Reuben John; Christianson, David W. (Elsevier, 2014)Background The diterpene cyclase ent-copalyl diphosphate synthase (CPS) catalyzes the first committed step in the biosynthesis of gibberellins. The previously reported 2.25 Å resolution crystal structure of CPS complexed ... -
Engineering of geranyl diphospate C-methyltransferase for the development of new diterpenoid precursors
Akıl, Caner (Izmir Institute of Technology, 2014)Terpenoids constitute the most diverse family of natural products. They are involved in several biological functions and are used in medical and industrial applications. The key to their diverse biological activities is ... -
Investigation of the effect of 4'-alkylıklavuzon derivatives on nucleotide synthesis and nucleocytoplasmic transport
Kutluer, Meltem (Izmir Institute of Technology, 2016-07)In anti-cancer agent development studies one of the most significant issue is to get an agent that specifically targets cancer cells without any effects on healthy cells. Goniothalamin, that is a styryl lactone isolated ... -
Purification and biochemical characterization of xylanase expressed in thermophilic Geobacillus sp.
Algan, Müge (Izmir Institute of Technology, 2015-12)Xylanase is an enzyme that catalyzes the degradation of the linear polysaccharide β-1,4-xylan into xylose and breaks down the hemicellulose structure of plant cell wall. The xylanolytic property of the enzyme makes it ... -
Structural studies of geosmin synthase, a bifunctional sesquiterpene synthase with αα domain architecture that catalyzes a unique cyclization-fragmentation reaction sequence
Harris, Golda G.; Lombardi, Patrick M.; Pemberton, Travis A.; Matsui, Tsutomu; Weiss, Thomas M.; Cole, Kathryn E.; Köksal, Mustafa; Murphy, Frank V.; Vedula, L. Sangeetha; Chou, Wayne K. W.; Cane, David E.; Christianson, David W. (American Chemical Society, 2015-12)Geosmin synthase from Streptomyces coelicolor (ScGS) catalyzes an unusual, metal-dependent terpenoid cyclization and fragmentation reaction sequence. Two distinct active sites are required for catalysis: the N-terminal ...
