Browsing by Author "Dağlıoğlu, Cenk"
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Cloning, expression, and activity analysis of human cathepsin C in the yeast pichia pastoris
Dağlıoğlu, Cenk (TÜBİTAK, 2017)The yeast Pichia pastoris expression system was investigated for the production of human cathepsin C (CatC) recombinant protein. The full-length CatC cDNA, corresponding to amino acids 12-475, was synthesized from interleukin-2 ... -
Enhancing tumor cell response to multidrug resistance with pH-sensitive quercetin and doxorubicin conjugated multifunctional nanoparticles
Dağlıoğlu, Cenk (Elsevier, 2017-08)Classical chemotherapy uses chemotherapeutic agents as a mainstay of anticancer treatment. However, the development of multidrug resistance to chemotherapy limits the effectiveness of current cancer treatment. Nanosized ... -
Environmentally responsive dual-targeting nanoparticles: Improving drug accumulation in cancer cells as a way of preventing anticancer drug efflux
Dağlıoğlu, Cenk (American Pharmacists Association, 2018-03)Drug targeting and stimuli-responsive drug release are 2 active areas of cancer research and hold tremendous potential in the management of cancer drug resistance. In this study, I addressed this issue and focused on the ... -
Synthesis and characterization of AICAR and DOX conjugated multifunctional nanoparticles as a platform for synergistic inhibition of cancer cell growth
Dağlıoğlu, Cenk; Okutucu, Burcu (American Chemical Society, 2016-04-20)The success of cancer treatment depends on the response to chemotherapeutic agents. However, malignancies often acquire resistance to drugs if they are used frequently. Combination therapy involving both a chemotherapeutic ... -
Therapeutic effects of AICAR and DOX conjugated multifunctional nanoparticles in sensitization and elimination of cancer cells via survivin targeting
Dağlıoğlu, Cenk; Okutucu, Burcu (Springer, 2017-01)Purpose: Resistance to chemotherapy is one of the major problems facing current cancer research. Enhancing tumor cell response to anticancer agents increases chemotherapeutic effectiveness. We have recently addressed this ...
